In February 2025, a medical team at UCSF delivered the first personalized CRISPR therapy to an infant with CPS1 deficiency, a rare metabolic disorder that prevents the body from breaking down ammonia. The treatment was designed specifically for that child's genetic mutation, built from scratch as a one-time intervention outside any clinical trial. For families navigating rare pediatric diagnoses, that news raises the question everyone asks: does this apply to my child? The short answer is that most children with rare disorders won't qualify for personalized CRISPR therapy in the next few years. But the infrastructure being built right now, including the research centers, clinical trials, and specialized expertise at major children's hospitals, will determine which conditions move from "in development" to "available" over the next decade. Knowing where that infrastructure exists and what questions to ask your care team matters more than following every breakthrough announcement. What CRISPR Does and What It Doesn't Fix. CRISPR is a gene editing tool. It cuts DNA at a specific location and either removes a faulty segment, inserts a corrected one, or turns a gene on or off. When it works, it addresses the genetic cause of a disease rather than managing symptoms. That precision is what makes it powerful for rare disorders. Many of these conditions are caused by a single mutation in a known gene. If you can fix that mutation, you can stop the disease progression. But CRISPR doesn't work for every rare disorder. It's most effective when the genetic...

The first personalized CRISPR therapy was delivered to an infant in February 2025. What this means for your child's eligibility.

CRISPR Gene Therapy for Rare Pediatric Disorders: What Families Need to Know

In February 2025, a medical team at UCSF delivered the first personalized CRISPR therapy to an infant with CPS1 deficiency, a rare metabolic disorder that prevents the body from breaking down ammonia. The treatment was designed specifically for that child's genetic mutation, built from scratch as a one-time intervention outside any clinical trial. For families navigating rare pediatric diagnoses, that news raises the question everyone asks: does this apply to my child? The short answer is that most children with rare disorders won't qualify for personalized CRISPR therapy in the next few years. But the infrastructure being built right now, including the research centers, clinical trials, and specialized expertise at major children's hospitals, will determine which conditions move from "in development" to "available" over the next decade. Knowing where that infrastructure exists and what questions to ask your care team matters more than following every breakthrough announcement. What CRISPR Does and What It Doesn't Fix. CRISPR is a gene editing tool. It cuts DNA at a specific location and either removes a faulty segment, inserts a corrected one, or turns a gene on or off. When it works, it addresses the genetic cause of a disease rather than managing symptoms. That precision is what makes it powerful for rare disorders. Many of these conditions are caused by a single mutation in a known gene. If you can fix that mutation, you can stop the disease progression. But CRISPR doesn't work for every rare disorder. It's most effective when the genetic...

Your child has a rare disorder. The school district has never served a student with this condition. When you request an IEP evaluation, staff tell you they don't know how to write accommodations for something they've never seen before. This is not a valid reason to delay or deny services. IDEA (the Individuals with Disabilities Education Act) protects all children with disabilities that impact their education, regardless of whether the diagnosis has a name, whether staff have prior experience with it, or whether anyone at the district knows what it is. Eligibility is based on educational impact, not diagnosis recognition. Why "We've Never Seen This Before" Doesn't Matter. School districts evaluate children based on how a disability affects their ability to access education. They don't diagnose medical conditions. They assess educational need. A child with a rare metabolic disorder who fatigues after 30 minutes of cognitive work qualifies for accommodations based on that functional limitation. The district doesn't need to understand the metabolic pathway. They need to understand that the child can't sustain attention through a 90-minute block without support. IDEA's 13 disability categories include "Other Health Impairment," which covers conditions that limit strength, vitality, or alertness due to chronic or acute health problems. This category exists specifically for conditions that don't fit neatly into other buckets. Rare disorders with educational impact qualify here. If your child's condition is so rare that it's undiagnosed or doesn't have an established name, that doesn't change anything. The evaluation measures functional limitations in...

When your child's condition is so rare that school staff have never seen it, IDEA still protects them. Here's how to advocate.

IEP Advocacy for Children with Rare Disorders: When No One Has Done This Before

Your child has a rare disorder. The school district has never served a student with this condition. When you request an IEP evaluation, staff tell you they don't know how to write accommodations for something they've never seen before. This is not a valid reason to delay or deny services. IDEA (the Individuals with Disabilities Education Act) protects all children with disabilities that impact their education, regardless of whether the diagnosis has a name, whether staff have prior experience with it, or whether anyone at the district knows what it is. Eligibility is based on educational impact, not diagnosis recognition. Why "We've Never Seen This Before" Doesn't Matter. School districts evaluate children based on how a disability affects their ability to access education. They don't diagnose medical conditions. They assess educational need. A child with a rare metabolic disorder who fatigues after 30 minutes of cognitive work qualifies for accommodations based on that functional limitation. The district doesn't need to understand the metabolic pathway. They need to understand that the child can't sustain attention through a 90-minute block without support. IDEA's 13 disability categories include "Other Health Impairment," which covers conditions that limit strength, vitality, or alertness due to chronic or acute health problems. This category exists specifically for conditions that don't fit neatly into other buckets. Rare disorders with educational impact qualify here. If your child's condition is so rare that it's undiagnosed or doesn't have an established name, that doesn't change anything. The evaluation measures functional limitations in...

When your child's condition is so rare that school staff have never seen it, IDEA still protects them. Here's how to advocate.

The average US tariff rate climbed to roughly 17% in 2025 — the highest in three decades, up from less than 3% before. Pharmaceutical tariffs proposed by mid-to-late 2026 could reach 200%. While the Supreme Court struck down certain IEEPA-based tariffs on February 20, 2026, tariffs imposed under other statutory authorities remain in effect. Goldman Sachs estimates that consumers will absorb roughly 70% of tariff costs in 2026 as inventories deplete, translating to $592 billion in higher prices for US households. For families navigating disability, that translates directly to wheelchairs, walkers, adaptive equipment, AAC devices, and specialty medications. Most durable medical equipment is manufactured in China and Southeast Asia. AAC hardware comes from abroad. Specialty medications for rare diseases often depend on foreign active pharmaceutical ingredients. When tariff chains hit those supply lines, the end price rises — and families already fighting insurance denials face a new barrier. What's Getting More Expensive. Durable medical equipment: Wheelchairs, walkers, patient lifts, adaptive seating, positioning devices. Manufacturing is concentrated overseas; tariff costs pass through distributors and land on retail and insurance reimbursement rates. AAC devices: Speech-generating devices, communication tablets, eye-gaze hardware. Most components are manufactured abroad. Even software-only solutions run on hardware subject to tariffs. Pharmaceutical products: Specialty medications for rare genetic conditions, seizure disorders, metabolic diseases. Many rely on imported active ingredients or are manufactured entirely outside the US. Proposed tariffs up to 200% could make some medications financially inaccessible. Replacement parts and repairs: Wheelchair wheels, joystick controllers,...

Tariffs Are Raising the Cost of Wheelchairs, AAC Devices, and Medications — What Families Can Do

The average US tariff rate climbed to roughly 17% in 2025 — the highest in three decades, up from less than 3% before. Pharmaceutical tariffs proposed by mid-to-late 2026 could reach 200%. While the Supreme Court struck down certain IEEPA-based tariffs on February 20, 2026, tariffs imposed under other statutory authorities remain in effect. Goldman Sachs estimates that consumers will absorb roughly 70% of tariff costs in 2026 as inventories deplete, translating to $592 billion in higher prices for US households. For families navigating disability, that translates directly to wheelchairs, walkers, adaptive equipment, AAC devices, and specialty medications. Most durable medical equipment is manufactured in China and Southeast Asia. AAC hardware comes from abroad. Specialty medications for rare diseases often depend on foreign active pharmaceutical ingredients. When tariff chains hit those supply lines, the end price rises — and families already fighting insurance denials face a new barrier. What's Getting More Expensive.  Durable medical equipment: Wheelchairs, walkers, patient lifts, adaptive seating, positioning devices. Manufacturing is concentrated overseas; tariff costs pass through distributors and land on retail and insurance reimbursement rates.  AAC devices: Speech-generating devices, communication tablets, eye-gaze hardware. Most components are manufactured abroad. Even software-only solutions run on hardware subject to tariffs.  Pharmaceutical products: Specialty medications for rare genetic conditions, seizure disorders, metabolic diseases. Many rely on imported active ingredients or are manufactured entirely outside the US. Proposed tariffs up to 200% could make some medications financially inaccessible.  Replacement parts and repairs: Wheelchair wheels, joystick controllers,...

In a study released April 9, 2012 by Pediatrics, researchers looked at the possible link between metabolic conditions and autism. While there were more cases of autism amongst mothers with metabolic conditions, such as diabetes, obesity, and hypertension, metabolic conditions do not cause autism. While the research is interesting, most experts agree that this research does not account for the startling increase in the number of cases of autism. The study found that women with diabetes or hypertension were 1.61 times more likely to have a child with an autism spectrum disorder, and they were also 2.35 times more likely to have a child with developmental disabilities than women without these metabolic conditions. With the CDC's announcement in March that 1 in 88 children have autism, people are looking for answers. In the study published April 9, researchers led by UC Davis epidemiologist Paula Krakowiak investigated 1,004 California children between the ages of 2 and 5. 512 of these children had an autism spectrum disorder, 172 had developmental disabilities, and 312 of the children showed typical development. There was not a statistically significant relationship between autism and diabetes, but there was a slight link between diabetes and developmental disabilities. While most of the media is now pointing to obesity as a cause of autism, remember that this study looked at only 1,000 children, and it only proposes a link between the two conditions, and not a causal relationship....

Study suggests link between maternal obesity, diabetes, hypertension and higher autism, developmental disability risk in children.

Obesity Linked to Autism

 In a study released April 9, 2012 by Pediatrics, researchers looked at the possible link between metabolic conditions and autism. While there were more cases of autism amongst mothers with metabolic conditions, such as diabetes, obesity, and hypertension, metabolic conditions do not cause autism.    While the research is interesting, most experts agree that this research does not account for the startling increase in the number of cases of autism.   The study found that women with diabetes or hypertension were 1.61 times more likely to have a child with an autism spectrum disorder, and they were also 2.35 times more likely to have a child with developmental disabilities than women without these metabolic conditions.   With the CDC's announcement in March that 1 in 88 children have autism, people are looking for answers. In the study published April 9, researchers led by UC Davis epidemiologist Paula Krakowiak investigated 1,004 California children between the ages of 2 and 5. 512 of these children had an autism spectrum disorder, 172 had developmental disabilities, and 312 of the children showed typical development.   There was not a statistically significant relationship between autism and diabetes, but there was a slight link between diabetes and developmental disabilities.   While most of the media is now pointing to obesity as a cause of autism, remember that this study looked at only 1,000 children, and it only proposes a link between the two conditions, and not a causal relationship....

Your child's neurologist just told you the seizures are medication resistant. You've tried three anticonvulsants. Maybe four. Each one came with side effects, and none of them worked well enough. Now you're hearing about dietary therapy from other parents online, and you need to know what the evidence shows. The ketogenic diet isn't alternative medicine. It's an evidence-based neurological intervention that's been used for drug-resistant epilepsy since the 1920s. About 20 to 30 percent of children with epilepsy don't respond adequately to medications. For many of these families, dietary therapy becomes the next conversation with their neurologist. Here's what you need to know about ketogenic and modified Atkins diets for childhood epilepsy, including how they work, what the research shows, and what families face when they commit to these protocols. How Dietary Therapy Works for Seizures. The ketogenic diet shifts your child's brain from running primarily on glucose to running on ketones. When carbohydrate intake is drastically restricted, the liver converts fat into ketone bodies. The brain uses these ketones for energy instead of glucose. This metabolic shift appears to reduce seizure activity through multiple mechanisms. Ketones stabilize neuronal membranes, modulate neurotransmitter function, and reduce oxidative stress in brain tissue. The exact mechanisms aren't fully understood, but the clinical effect is well documented: many children who don't respond to medications experience significant seizure reduction on a ketogenic diet. The classical ketogenic diet uses a 3:1 or 4:1 ratio of fat to combined protein and carbohydrates by weight. That's extremely high...

Guide to ketogenic and modified Atkins diets for drug-resistant childhood epilepsy, including how they work and what to expect.

Dietary Therapy for Epilepsy: A Parent's Guide to Ketogenic and Modified Atkins Diets

Your child's neurologist just told you the seizures are medication resistant. You've tried three anticonvulsants. Maybe four. Each one came with side effects, and none of them worked well enough. Now you're hearing about dietary therapy from other parents online, and you need to know what the evidence shows. The ketogenic diet isn't alternative medicine. It's an evidence-based neurological intervention that's been used for drug-resistant epilepsy since the 1920s. About 20 to 30 percent of children with epilepsy don't respond adequately to medications. For many of these families, dietary therapy becomes the next conversation with their neurologist. Here's what you need to know about ketogenic and modified Atkins diets for childhood epilepsy, including how they work, what the research shows, and what families face when they commit to these protocols. How Dietary Therapy Works for Seizures. The ketogenic diet shifts your child's brain from running primarily on glucose to running on ketones. When carbohydrate intake is drastically restricted, the liver converts fat into ketone bodies. The brain uses these ketones for energy instead of glucose. This metabolic shift appears to reduce seizure activity through multiple mechanisms. Ketones stabilize neuronal membranes, modulate neurotransmitter function, and reduce oxidative stress in brain tissue. The exact mechanisms aren't fully understood, but the clinical effect is well documented: many children who don't respond to medications experience significant seizure reduction on a ketogenic diet. The classical ketogenic diet uses a 3:1 or 4:1 ratio of fat to combined protein and carbohydrates by weight. That's extremely high...

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Special Needs
Articles

CRISPR Gene Therapy for Rare Pediatric Disorders: What Families Need to Know

IEP Advocacy for Children with Rare Disorders: When No One Has Done This Before

Tariffs Are Raising the Cost of Wheelchairs, AAC Devices, and Medications — What Families Can Do

Obesity Linked to Autism

Dietary Therapy for Epilepsy: A Parent's Guide to Ketogenic and Modified Atkins Diets

Find Providers Near You

Special Needs Articles

CRISPR Gene Therapy for Rare Pediatric Disorders: What Families Need to Know

IEP Advocacy for Children with Rare Disorders: When No One Has Done This Before

Tariffs Are Raising the Cost of Wheelchairs, AAC Devices, and Medications — What Families Can Do

Obesity Linked to Autism

Dietary Therapy for Epilepsy: A Parent's Guide to Ketogenic and Modified Atkins Diets

Find Providers Near You

Special Needs
Articles